The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …

Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

Ras GTPases play a crucial role in cell signaling pathways. Mutations of the Ras gene occur
in about one third of cancerous cell lines and are often associated with detrimental clinical …

Abstract First-generation KRAS G12C inhibitors, such as sotorasib and adagrasib, are
limited by the depth and duration of clinical responses. One potential explanation for their …

RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act
as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP …

Abstract Self‐assemblies (ie, nanoclusters) of the RAS GTPase on the membrane act as
scaffolds that activate downstream RAF kinases and drive MAPK signaling for cell …

The KRAS mutation stands out as one of the most influential oncogenic mutations, which
directly regulates the hallmark features of cancer and interacts with other cancer-causing …

Pediatric low grade brain tumors and neurodevelopmental disorders share proteins,
signaling pathways, and networks. They also share germline mutations and an impaired …

Different exogenous electric fields (EF) can guide cell migration, disrupt proliferation, and
program cell development. Studies have shown that many of these processes were initiated …