Strategies and lessons learned from total synthesis of taxol

L Min, JC Han, W Zhang, CC Gu, YP Zou… - Chemical …, 2023 - ACS Publications
Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

[2+ 2+ 2] Cycloaddition reactions catalyzed by transition metal complexes

PR Chopade, J Louie - Advanced Synthesis & Catalysis, 2006 - Wiley Online Library
Recent progress in the synthesis of benzene and 1, 3‐cyclohexadiene derivatives, and
heterocyclic compounds such as pyridines, pyridones, pyrans, pyrimidine diones, etc, has …

Transition metal catalyzed [2+ 2+ 2] cycloaddition and application in organic synthesis

S Kotha, E Brahmachary, K Lahiri - European journal of organic …, 2005 - Wiley Online Library
Abstract The [2+ 2+ 2] cycloaddition strategy is complementary to the well known Diels–
Alder reaction for the generation of polycyclic compounds. This [2+ 2+ 2] approach is atom …

Cyclopentadienyl complexes of group 9 metals in the total synthesis of natural products

VB Kharitonov, DV Muratov, DA Loginov - Coordination Chemistry Reviews, 2022 - Elsevier
Organic transformations catalyzed by cyclopentadienyl complexes of Group 9 metals (cobalt,
rhodium and iridium) are the key steps of the total synthesis of various natural products …

Cyclobutarenes and related compounds

AK Sadana, RK Saini, WE Billups - Chemical reviews, 2003 - ACS Publications
Due to the thermodynamic stability associated with the aromatic system and the kinetic
reactivity of the strained cyclobutene ring, the cyclobutarenes represent a unique class of …

[PDF][PDF] Cotrimerizations of acetylenic compounds

N Agenet, O Buisine, F Slowinski… - Organic …, 2007 - chemistry-chemists.com
The cyclotrimerization of acetylenic compounds is a useful method for the construction of
three new bonds in a one-step process. Although symmetry-allowed, there is a paucity of …

Recent progress in cobalt-mediated [2+ 2+ 2] cycloaddition reactions

V Gandon, C Aubert, M Malacria - Chemical communications, 2006 - pubs.rsc.org
Recent progress in cobalt-mediated [2 + 2 + 2] cycloaddition reactions - Chemical
Communications (RSC Publishing) DOI:10.1039/B517696B Royal Society of Chemistry View …

Cobalt-catalysed carbon-carbon bond-formation reactions

W Hess, J Treutwein, G Hilt - Synthesis, 2008 - thieme-connect.com
The recent developments in cobalt catalysis are compiled in this review covering the years
2000 through 2007. Special focus is directed towards cobalt-catalysed ring-formation …

Ni0-Catalyzed Regioselective [2 + 2 + 2] Cyclotrimerization of 1,3-Diynes: An Expeditious Synthesis of Hexasubstituted Alkynyl Benzenes

R Chakrabortty, S Ghosh, V Ganesh - Organic Letters, 2024 - ACS Publications
In the present work, we demonstrate a regioselective [2+ 2+ 2] cyclotrimerization of 1, 3-
diynes catalyzed by Ni0 to provide hexasubstituted benzenes (HSBs). HSBs have significant …

Demonstration of “Möbius” aromaticity in planar metallacycles

M Mauksch, SB Tsogoeva - Chemistry–A European Journal, 2010 - Wiley Online Library
Mçbius aromaticity, predicted by Edgar Heilbronner in 1964, is a stabilizing effect exhibited
by 4n electron fully conjugated cyclic molecules (or transition states) with an odd number of …