The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei
Cell morphology encodes essential information on many underlying biological processes. It
is commonly used by clinicians and researchers in the study, diagnosis, prognosis, and …
is commonly used by clinicians and researchers in the study, diagnosis, prognosis, and …
Three-dimensional cell migration does not follow a random walk
Cell migration through 3D extracellular matrices is critical to the normal development of
tissues and organs and in disease processes, yet adequate analytical tools to characterize …
tissues and organs and in disease processes, yet adequate analytical tools to characterize …
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions
Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …
independently implicated as regulators of cell motility, including pore size, crosslink density …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
Actin-based cell protrusion in a 3D matrix
PT Caswell, T Zech - Trends in cell biology, 2018 - cell.com
Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …
Modes of invasion during tumour dissemination
P Pandya, JL Orgaz, V Sanz‐Moreno - Molecular oncology, 2017 - Wiley Online Library
Cancer cell migration and invasion underlie metastatic dissemination, one of the major
problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly …
problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly …
Personalized immunotherapy against several neuronal and brain tumors
S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
Following uncontrolled proliferation, a subset of primary tumour cells acquires additional
traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized …
traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized …
The fundamental role of mechanical properties in the progression of cancer disease and inflammation
CT Mierke - Reports on Progress in Physics, 2014 - iopscience.iop.org
The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …
underinvestigated and even ignored in many oncological and immunological reviews. In …