Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an
important mechanism for the regulation of information storage and the control of actions, as …

Diacylglycerol signals by binding and activating C1 domain-containing proteins expressed
principally in neuronal and immune tissues. This restricted expression profile suggests that …

Background Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs
display a vast array of phenotypes that differ from their ancestors, yet mirror other …

Fragile X syndrome (FXS) is caused by the absence of the Fragile X Mental Retardation
Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated with an excessive …

Obesity is genetically heterogeneous with monogenic and complex polygenic forms. Using
exome and targeted sequencing in 2,737 severely obese cases and 6,704 controls, we …

How early life experience is translated into storable epigenetic information leading to
behavioral changes remains poorly understood. Here we found that Zika virus (ZIKV) …

The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into
phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide …

Ten mammalian diacylglycerol kinase (DGK) isozymes (a-γ) have been identified. Recent
studies have revealed that DGK isozymes play pivotal roles in a wide variety of …

Lipids play a vital role in the health and functioning of neurons and interest in the
physiological role of neuronal lipids is certainly increasing. One neuronal function in which …

Synaptic adhesion molecules regulate synapse development and plasticity through
mechanisms that include trans-synaptic adhesion and recruitment of diverse synaptic …