Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that
causes significant disability and healthcare burden. The treatment of MS has evolved over …

Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Stem cells are a population of undifferentiated cells characterized by the ability to
extensively proliferate (self-renewal), usually arise from a single cell (clonal), and …

Importance Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in
aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies …

The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …

Background Alemtuzumab, a humanized monoclonal antibody that targets CD52 on
lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis …

Mesenchymal stem cells/marrow stromal cells (MSCs) present a promising tool for cell
therapy, and are currently being tested in US FDA-approved clinical trials for myocardial …

The concept of the CNS as an immune-privileged organ has led to a common
misunderstanding that it is not an active immunological organ, guarded from its …