Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Chromosome segregation and cell division are essential, highly ordered processes that
depend on numerous protein complexes. Results from recent RNA interference screens …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

Despite many decades of study, mitotic chromosome structure and composition remain
poorly characterized. Here, we have integrated quantitative proteomics with bioinformatic …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore
must remain attached to depolymerizing microtubules, which drive chromosome …

Linear motifs are short segments of multidomain proteins that provide regulatory functions
independently of protein tertiary structure. Much of intracellular signalling passes through …

DNA repair is essential to maintain genome integrity, and genes with roles in DNA repair are
frequently mutated in a variety of human diseases. Repair via homologous recombination …

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a well-known regulator of
chromosome separation and cell division, which plays an important role in cell proliferation …