CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Renal cell carcinomas (RCCs) of different histologic subtypes differ in their prognosis and
therapeutic response; therefore, it is important to classify malignant epithelial tumors of the …

Background: Activation of the KIT receptor tyrosine kinase is associated with the
development of canine mast cell tumors (MCT). Hypothesis/Objective: To evaluate the …

Context.—The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell
renal cell carcinoma using light microscopy remains problematic in some cases. Objective …

Kidney intercalated cells are involved in acid-base homeostasis via vacuolar ATPase
expression. Here we report six human intercalated cell subtypes, including hybrid principal …

Apoptosis of tubular epithelial cells is a hallmark of acute kidney injury (AKI), but the cellular
events preceding apoptosis in this setting are incompletely understood. Because matrix …

C-KIT (CD117), a tyrosine kinase receptor, is involved in the growth and development of
normal tissues and some types of neoplasms. In the present study we analysed the …

C-kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been
identified in several types of human neoplasms. Recently, KIT has been reported to be a …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …

The category of globally accepted neoplasms of the kidney continues to expand.
Recognition of new entities is very important for care of patients and their families. For …