The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Covering: 2011 to 2022 The natural world is a prolific source of some of the most interesting,
rare, and complex molecules known, harnessing sophisticated biosynthetic machinery …

A five-step total synthesis of arborisidine, a caged pentacyclic monoterpene indole alkaloid,
has been accomplished in both racemic and enantioselective manners. The synthesis …

Total synthesis is considered by many as the finest combination of art and science. During
the last decades, several concepts were proposed for achieving the perfect vision of total …

Indole-ynones have been established as general substrates for radical dearomatizing
spirocyclization cascade reactions. Five distinct and varied synthetic protocols have been …

With the ever-increasing scope of organocuprates, a well-established Gilman reagent has
been considered as an unprecedented synthetic tool in modern organic chemistry. The …

An intramolecular aza‐Prins cyclization of aza‐Achmatowicz rearrangement products was
developed in which bismuth tribromide (BiBr3) plays a dual role as an efficient Lewis acid …

The polycyclic core of the akuammiline alkaloids can be synthesized from simple tryptamine
and tryptophol derivatives via a Ag (I)-catalyzed enantioselective dearomative cyclization …

The first total synthesis of arborisidine, a unique Kopsia indole alkaloid possessing a fully
substituted cyclohexanone ring system with two quaternary carbons, has been achieved in …

An asymmetric dearomatization of indoles bearing α-diazoacetamide functionalities was
developed for synthesizing high-value spiro scaffolds. A silver phosphate chemoselectively …