New nucleoside analogues for the treatment of hemorrhagic fever virus infections

E De Clercq - Chemistry–An Asian Journal, 2019 - Wiley Online Library
Eight different compounds, all nucleoside analogues, could presently be considered as
potential drug candidates for the treatment of Ebola virus (EBOV) and/or other hemorrhagic …

Favipiravir in therapy of viral infections

R Łagocka, V Dziedziejko, P Kłos, A Pawlik - Journal of clinical medicine, 2021 - mdpi.com
Favipiravir (FPV) is a novel antiviral drug acting as a competitive inhibitor of RNA-dependent
RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved …

Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir

EP Tchesnokov, JY Feng, DP Porter, M Götte - Viruses, 2019 - mdpi.com
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …

[HTML][HTML] Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus

Z Xu, X Liu, X Ma, W Zou, Q Chen, F Chen, X Deng… - Cell insight, 2022 - Elsevier
Annual and sporadic influenza outbreaks pose a great threat to human health and the
economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen …

Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis

K Wagatsuma, IS Koolhof, Y Shobugawa… - BMC Infectious …, 2021 - Springer
Abstract Background Non-pharmaceutical interventions (NPIs), such as sanitary measures
and travel restrictions, aimed at controlling the severe acute respiratory syndrome …

Drug repurposing approach to combating coronavirus: Potential drugs and drug targets

J Xu, Y Xue, R Zhou, PY Shi, H Li… - Medicinal research …, 2021 - Wiley Online Library
In the past two decades, three highly pathogenic human coronaviruses severe acute
respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome …

Discovery of aryl benzoyl hydrazide derivatives as novel potent broad-spectrum inhibitors of influenza A virus RNA-dependent RNA polymerase (RdRp)

X Liu, J Liang, Y Yu, X Han, L Yu, F Chen… - Journal of Medicinal …, 2022 - ACS Publications
Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are
extremely limited, which makes the development of novel anti-influenza drugs for the clinical …

[HTML][HTML] COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

S Kumar, M Basu, P Ghosh, U Pal, MK Ghosh - Genes & Diseases, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated
disease COVID-19. Clinicians are continuously facing huge problems in the treatment of …

A review of therapeutics in clinical development for respiratory syncytial virus and influenza in children

EG Nicholson, FM Munoz - Clinical therapeutics, 2018 - Elsevier
Purpose Respiratory syncytial virus (RSV) and influenza are important viral pathogens
worldwide. Children, in particular, bear considerable burdens of morbidity and mortality …

Was the reduction in seasonal influenza transmission during 2020 attributable to non-pharmaceutical interventions to contain coronavirus disease 2019 (COVID-19) in …

K Wagatsuma, IS Koolhof, R Saito - Viruses, 2022 - mdpi.com
We quantified the effects of adherence to various non-pharmaceutical interventions (NPIs)
on the seasonal influenza epidemic dynamics in Japan during 2020. The total monthly …