As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Viral infections have been proposed to elicit pathological processes leading to the initiation
of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this …

Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal
dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a …

Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating
adaptive immune responses. The functions of DCs were originally obscured by their overlap …

For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper
(Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has …

Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human
cancers respond to ICI immunotherapy and a large fraction of patients with the responsive …

Summary Interferon regulatory factor-8 (IRF8) has been proposed to be essential for
development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional …

The intestinal mucosa is a physiological barrier for most microbes, including both
commensal bacteria and invading pathogens. Under homeostatic conditions …