Self-medication and Anti-malarial Drug Resistance in the Democratic Republic of the Congo (DRC): A silent threat

A Akilimali, C Bisimwa, AT Aborode, C Biamba… - Tropical Medicine and …, 2022 - Springer
Background Malaria is a global infectious (vector-borne: Anopheles mosquitoes) disease
which is a leading cause of morbidity and mortality in Sub-Saharan Africa (SSA). Among all …

Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids

A Harbuzariu, S Pitts, JC Cespedes, KO Harp, A Nti… - Scientific Reports, 2019 - nature.com
Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium
falciparum infection, has a 20–30% mortality rate and predominantly affects African children …

Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria …

D Chilot, A Mondelaers, AZ Alem, MS Asres, MA Yimer… - Plos one, 2023 - journals.plos.org
Background Every 75 seconds, a child under five dies of malaria. Mainly children, aged
between six months and five years, are at the highest risk for malaria. These children lost …

A narrative review of the RTS S AS01 malaria vaccine and its implementation in Africa to reduce the global malaria burden

IJ Ogieuhi, VO Ajekiigbe, K Kolo-Manma… - Discover Public …, 2024 - Springer
Abstract The RTS, S/AS01 vaccine is a significant milestone in advancing malaria control,
especially in Africa, where the heavy burden of this disease is prevalent. The objective of …

Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo

J Okitawutshu, A Signorell, JC Kalenga, E Mukomena… - Malaria journal, 2022 - Springer
Background Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-
saving intervention for severe malaria in remote settings in Africa. Recognition of danger …

Factors influencing severity of recurrent malaria in a conflict-affected state of South Sudan: an unmatched case-control study

IO Idris, GO Ayeni, IO Iyamu, AB Sina-Odunsi… - Conflict and Health, 2022 - Springer
Background The burden of malaria remains the highest in sub-Saharan Africa and South
Sudan is not an exception. The country has borne the brunt of years of chronic warfare and …

Severe malaria burden, clinical spectrum and outcomes at Apac district hospital, Uganda: a retrospective study of routine health facility-based data

E Ocen, R Opito, C Tegu, A Oula, P Olupot-Olupot - Malaria Journal, 2023 - Springer
Background Most data describing severe malaria (SM) in sub-Saharan Africa (SSA) are from
research settings outside disease endemic areas. Using routinely collected data from Apac …

Malaria case fatality rate among children under five in Burkina Faso: an assessment of the spatiotemporal trends following the implementation of control programs

M Ouédraogo, DT Kangoye, S Samadoulougou… - International journal of …, 2020 - mdpi.com
Reducing the 2015 level of malaria mortality by 90% by 2030 is a goal set by the World
Health Organization (WHO). In Burkina Faso, several malaria control programs proven to be …

Profiling malaria infection among under-five children in the Democratic Republic of Congo

JBO Emina, HV Doctor, Y Yé - PloS one, 2021 - journals.plos.org
Introduction In 2018, Malaria accounted for 38% of the overall morbidity and 36% of the
overall mortality in the Democratic Republic of Congo (DRC). This study aimed to identify …

[HTML][HTML] Transcriptional profiles analysis of COVID-19 and malaria patients reveals potential biomarkers in children

N Lambert, JA Kengne-Ouafo, WM Rissy, U Diane… - BioRxiv, 2022 - ncbi.nlm.nih.gov
The clinical presentation overlap between malaria and COVID-19 poses special challenges
for rapid diagnosis in febrile children. In this study, we collected RNA-seq data of children …