The ageing brain: molecular and cellular basis of neurodegeneration
Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …
physiological deterioration and increased vulnerability to death. Ageing has also been …
Huntington's disease: mechanisms of pathogenesis and therapeutic strategies
M Jimenez-Sanchez, F Licitra… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
Epigenetic regulation and chromatin remodeling in learning and memory
S Kim, BK Kaang - Experimental & molecular medicine, 2017 - nature.com
Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …
[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
Axonal degeneration during aging and its functional role in neurodegenerative disorders
Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …
This represents a major health issue worldwide that is only expected to escalate due to the …
Oxidative stress and Huntington's disease: The good, the bad, and the ugly
Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …
Mechanisms of protein toxicity in neurodegenerative diseases
Protein toxicity can be defined as all the pathological changes that ensue from
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …