Inflammatory resolution: new opportunities for drug discovery

DW Gilroy, T Lawrence, M Perretti… - Nature reviews Drug …, 2004 - nature.com
Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …

PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

A Croasdell, PF Duffney, N Kim, SH Lacy… - PPAR …, 2015 - Wiley Online Library
The resolution of inflammation is an active and dynamic process, mediated in large part by
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …

Resolution of inflammation: mechanisms and opportunity for drug development

AL Alessandri, LP Sousa, CD Lucas, AG Rossi… - Pharmacology & …, 2013 - Elsevier
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Clostridium butyricum modulates the microbiome to protect intestinal barrier function in mice with antibiotic-induced dysbiosis

M Hagihara, Y Kuroki, T Ariyoshi, S Higashi, K Fukuda… - Iscience, 2020 - cell.com
Summary Clostridium butyricum MIYAIRI 588 (CBM 588) is a probiotic bacterium that has
previously been used to prevent antibiotic-associated diarrhea. However, the underlying …

Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?

RM Domingues, P Domingues, T Melo… - Journal of …, 2013 - Elsevier
Protein lipoxidation refers to the modification by electrophilic lipid oxidation products to form
covalent adducts, which for many years has been considered as a deleterious consequence …

Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of β-caryophyllene, a sesquiterpene

JY Cho, HJ Chang, SK Lee, HJ Kim, JK Hwang… - Life Sciences, 2007 - Elsevier
β-Caryophyllene (BCP), a naturally occurring plant sesquiterpene, was examined for anti-
inflammatory activity in a mouse model of experimental colitis induced by dextran sulfate …

Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats

M Sanchez-Hidalgo, AR Martin, I Villegas… - Biochemical …, 2005 - Elsevier
Recent studies have shown the implication of the peroxisome proliferator-activated receptor
gamma (PPARγ) in control of inflammation, immune and apoptotic responses during early …

[HTML][HTML] Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways

A Kamalian, MS Asl, M Dolatshahi… - World Journal of …, 2020 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) refers to a group of disorders characterized by chronic
inflammation of the gastrointestinal (GI) tract. The elevated levels of nitric oxide (NO) in …

Anti‐inflammatory effects of 5‐HT3 receptor antagonist, tropisetron on experimental colitis in rats

K Mousavizadeh, R Rahimian… - European journal of …, 2009 - Wiley Online Library
Background There is a pressing need for research that will lead to the development of new
therapeutic approaches for treating inflammatory bowel disease (IBD). The aim of this study …

Dietary modulation of peroxisome proliferator-activated receptor gamma

R Marion-Letellier, P Dechelotte, M Iacucci, S Ghosh - Gut, 2009 - gut.bmj.com
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that
regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be …