Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Models of traumatic brain injury-highlights and drawbacks

Q Zhao, J Zhang, H Li, H Li, F Xie - Frontiers in neurology, 2023 - frontiersin.org
Traumatic brain injury (TBI) is the leading cause for high morbidity and mortality rates in
young adults, survivors may suffer from long-term physical, cognitive, and/or psychological …

Experimental models of hospital-acquired infections after traumatic brain injury: Challenges and opportunities

N Gandasasmita, J Li, DJ Loane… - Journal of …, 2024 - liebertpub.com
Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased
risk of nosocomial infections, including bacterial pneumonia and other upper respiratory …

Animal model of repeated low-level blast traumatic brain injury displays acute and chronic neurobehavioral and neuropathological changes

AR Ravula, J Rodriguez, D Younger, V Perumal… - Experimental …, 2022 - Elsevier
Blast-induced neurotrauma (BINT) is not only a signature injury to soldiers in combat field
and training facilities but may also a growing concern in civilian population due to recent …

Behavioral and myelin-related abnormalities after blast-induced mild traumatic brain injury in mice

M Nonaka, WW Taylor, O Bukalo, LB Tucker… - Journal of …, 2021 - liebertpub.com
In civilian and military settings, mild traumatic brain injury (mTBI) is a common consequence
of impacts to the head, sudden blows to the body, and exposure to high-energy atmospheric …

Systemic inflammation induced from remote extremity trauma is a critical driver of secondary brain injury

CJ Rowe, J Mang, B Huang, K Dommaraju… - Molecular and Cellular …, 2023 - Elsevier
Blast exposure, commonly experienced by military personnel, can cause devastating life-
threatening polysystem trauma. Despite considerable research efforts, the impact of the …

RORγt-Expressing Pathogenic CD4+ T Cells Cause Brain Inflammation during Chronic Colitis

ME Mickael, S Bhaumik, A Chakraborti… - The Journal of …, 2022 - journals.aai.org
Neurobehavioral disorders and brain abnormalities have been extensively reported in both
Crohn's disease and ulcerative colitis patients. However, the mechanism causing …

Longitudinal dynamics of microvascular recovery after acquired cortical injury

X Lin, L Chen, A Jullienne, H Zhang, A Salehi… - Acta neuropathologica …, 2022 - Springer
Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs
blood flow to injured tissues. There are reports of vascular morphological recovery following …

An update on repeated blast traumatic brain injury

AR Ravula, T Das, A Gosain, T Dolalas, S Padhi… - Current Opinion in …, 2022 - Elsevier
Abstract Service members and law enforcement experience repeated blast exposures
frequently due to the constant use of heavy weaponry, including large caliber rifles and …

DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury

MM Díaz, Y Tsenkina, D Arizanovska… - Cell Death & …, 2023 - nature.com
Hallmark pathological features of brain trauma are axonal degeneration and demyelination
because myelin-producing oligodendrocytes (OLs) are particularly vulnerable to injury …