[PDF][PDF] Role and regulation of RUNX2 in osteogenesis
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
Review of signaling pathways governing MSC osteogenic and adipogenic differentiation
AW James - Scientifica, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
The RUNX family: developmental regulators in cancer
Y Ito, SC Bae, LSH Chuang - Nature Reviews Cancer, 2015 - nature.com
RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …
regulators of development. They are frequently deregulated in human cancers, indicating a …
Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast …
KS Lee, HJ Kim, QL Li, XZ Chi, C Ueta… - … and cellular biology, 2000 - Am Soc Microbiol
When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth
factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone …
factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone …
Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
A Yamaguchi, T Komori, T Suda - Endocrine reviews, 2000 - academic.oup.com
Osteoblasts arise from common progenitors with chondrocytes, muscle and adipocytes, and
various hormones and local factors regulate their differentiation. We review here regulation …
various hormones and local factors regulate their differentiation. We review here regulation …
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
GS Stein, JB Lian, AJ Van Wijnen, JL Stein… - Oncogene, 2004 - nature.com
We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
Core-binding factors in haematopoiesis and leukaemia
NA Speck, DG Gilliland - Nature Reviews Cancer, 2002 - nature.com
Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2αA) is inhibited by tumor necrosis factor-α
L Gilbert, X He, P Farmer, J Rubin, H Drissi… - Journal of Biological …, 2002 - ASBMB
The transcription factor RUNX2 (Cbfa1/AML3/Pebp2αA) is a critical regulator of osteoblast
differentiation. We investigated the effect of the inflammatory cytokine tumor necrosis factor α …
differentiation. We investigated the effect of the inflammatory cytokine tumor necrosis factor α …
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1 …
S Takeda, JP Bonnamy, MJ Owen, P Ducy… - Genes & …, 2001 - genesdev.cshlp.org
Chondrocyte hypertrophy is a mandatory step during endochondral ossification. Cbfa1-
deficient mice lack hypertrophic chondrocytes in some skeletal elements, indicating that …
deficient mice lack hypertrophic chondrocytes in some skeletal elements, indicating that …
The RUNX genes: gain or loss of function in cancer
K Blyth, ER Cameron, JC Neil - Nature Reviews Cancer, 2005 - nature.com
The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …
regulators of cell fate in development and their paradoxical effects in cancer, in which they …