Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth
factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone …

Osteoblasts arise from common progenitors with chondrocytes, muscle and adipocytes, and
various hormones and local factors regulate their differentiation. We review here regulation …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

The transcription factor RUNX2 (Cbfa1/AML3/Pebp2αA) is a critical regulator of osteoblast
differentiation. We investigated the effect of the inflammatory cytokine tumor necrosis factor α …

Chondrocyte hypertrophy is a mandatory step during endochondral ossification. Cbfa1-
deficient mice lack hypertrophic chondrocytes in some skeletal elements, indicating that …

The RUNX genes have come to prominence recently because of their roles as essential
regulators of cell fate in development and their paradoxical effects in cancer, in which they …