For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant
impact on outcomes, including mortality and morbidities. Unfortunately, apart from …

Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …

Erythropoietin (Epo) is produced by renal Epo-producing cells (REPs) in a hypoxia-inducible
manner. The conversion of REPs into myofibroblasts and coincident loss of Epo-producing …

Activation of the intrarenal renin-angiotensin system (RAS) can elicit hypertension
independently from the systemic RAS. However, the precise mechanisms by which …

An essential link between the kidney and blood pressure control has long been known.
Here, we review evidence supporting the premise that an impaired capacity of the kidney to …

Renin–angiotensin–aldosterone system (RAAS) plays important roles in regulating renal
hemodynamics and functions, as well as in the pathophysiology of hypertension and renal …

Podocytes are critical in the maintenance of a healthy glomerular filter; however, they have
been difficult to study in the intact kidney because of technical limitations. Here we report the …