Laboratory survival experiments have shown that dietary restriction (DR) can increase
median and maximum lifespan. This paper provides a meta-analysis of laboratory …

The premise of genetic analysis is that a causal link exists between phenotypic and allelic
variation. However, it has long been documented that mutant phenotypes are not a simple …

Background A laboratory inbred strain of the annual fish Nothobranchius furzeri shows
exceptionally short life expectancy and accelerated expression of age markers. In this study …

Survivorship experiments play a central role in aging research and are performed to
evaluate whether interventions alter the rate of aging and increase lifespan. The accelerated …

The short‐lived annual fish Nothobranchius furzeri shows extremely short captive life span
and accelerated expression of age markers, making it an interesting model system to …

Finding the specific nucleotides that underlie adaptive variation is a major goal in
evolutionary biology, but polygenic traits pose a challenge because the complex genotype …

Представлен аналитический обзор достижений генетики старения и
продолжительности жизни. Обобщены эволюционные, клеточные и молекулярно …

A central issue in evolutionary quantitative genetics is to understand how genetic variation
for quantitative traits is maintained in natural populations. Estimates of genetic variation and …

Drosophila is a genetically tractable system ideal for investigating the mechanisms of aging
and developing interventions for promoting healthy aging. Here we describe methods …

Two classic theories maintain that aging evolves either because of alleles whose
deleterious effects are confined to late life or because of alleles with broad pleiotropic effects …