Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …
Urinary microbiome: yin and yang of the urinary tract
V Perez-Carrasco, A Soriano-Lerma… - Frontiers in cellular …, 2021 - frontiersin.org
The application of next generation sequencing techniques has allowed the characterization
of the urinary tract microbiome and has led to the rejection of the pre-established concept of …
of the urinary tract microbiome and has led to the rejection of the pre-established concept of …
Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections
Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a
pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched …
pathogen's susceptibility, with less attention paid to the risk that even susceptibility-matched …
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of
infection being a significant risk factor. While the gut is a known reservoir for uropathogenic …
infection being a significant risk factor. While the gut is a known reservoir for uropathogenic …
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in
antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation …
antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation …
Antibiotic-induced collateral damage to the microbiota and associated infections
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …
Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation
Organ transplantation is a life-saving treatment for patients with end-stage disease, but
survival rates after transplantation vary considerably. There is now increasing evidence that …
survival rates after transplantation vary considerably. There is now increasing evidence that …
The role of gut, vaginal, and urinary microbiome in urinary tract infections: from bench to bedside
The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the
contamination of the periurethral space by specific uropathogens residing in the gut, which …
contamination of the periurethral space by specific uropathogens residing in the gut, which …
Recurrent urinary tract infection: a mystery in search of better model systems
BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
Urinary tract infections: Pathogenesis, host susceptibility and emerging therapeutics
MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …
account for an estimated 400 million infections and billions of dollars in health-care …