BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor
genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered …

Current methods of next generation sequencing may simultaneously detect multiple
germline breast cancer susceptibility variants. However, it is a challenge to maximize the …

The most common breast cancer (BC) susceptibility genes beyond BRCA1/2 are ATM and
CHEK2. For the purpose of exploring the clinicopathologic characteristics of BC developed …

Abstract Background Whereas the National Comprehensive Cancer Network (NCCN)
criteria restrict germline-genetic testing (GGT) to a subset of breast cancer (BC) patients, the …

Background The impact of ATM, CHEK2, and PALB2, the three most prevalent moderate-risk
breast cancer genes, on surgical decision making is not well known. Methods Our …

This study aims to assess potential complications and effects on the magnetic resonance
imaging (MRI) image quality of a new MRI-conditional breast tissue expander (Motiva …

Background Contralateral prophylactic mastectomy (CPM) has been performed for several
decades in patients with unilateral breast cancer (BC). However, the survival benefits of …

Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality
approach, depending on the stage and biology of the tumour and the acceptance and …

Introduction Although central breast cancer is not a contraindication to breast conserving,
most surgeons still choose to perform total mastectomy. The safety of breast conserving …

Background Carriers of deleterious mutations in breast cancer predisposition genes are
presented with critical choices regarding cancer risk management. Risk-reduction …