The stratum corneum, the most superficial layer of the skin, protects the body against
environmental hazards and presents a highly selective barrier for the passage of drugs and …

From a clinical perspective, local anesthetics have rather widespread application in regional
blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer …

Acetazolamide (ACZ), a carbonic anhydrase inhibitor, is employed to decrease the
intraocular pressure (IOP) in glaucoma patients. ACZ is characterized by low aqueous …

The main objective of this study was to evaluate the most suitable conditions to prepare 5-
fluorouracil (5-FU) loaded chitosan nanoparticles (CSNPs). 5-FU loaded CSNPs were …

The goal of this study was the development and evaluation of semisolid caffeine (CAF)
loaded nanostructured lipid carriers (NLCs) for topical treatment of cellulite. CAF-loaded …

In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the
reason that patients abandon treatment. Topical anesthetics are applied in order to minimize …

The present study was designed to develop dorzolamide HCl (DRZ) loaded cationic
nanoemulsions (CNEs) for enhanced ocular delivery. CNEs were prepared employing high …

The aim of the present study is to enhance the skin penetration and deposition of 8-
methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8 …

Introduction: There is a clinical need for pharmaceutical dosage forms devised to prolong
the acting time of local anesthetic (LA) agents or to reduce their toxicity. Encapsulation of LA …

Cancer was ranked as the second leading cause of death, and colon cancer is recognized
as third most common cancer worldwide with high morbidity and mortality …