Mechanisms of Altered Ca2+ Handling in Heart Failure
M Luo, ME Anderson - Circulation research, 2013 - Am Heart Assoc
Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias
PD Swaminathan, A Purohit, TJ Hund… - Circulation …, 2012 - Am Heart Assoc
Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …
suffering and sudden death, remains an unmet goal for biomedical researchers and …
Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy
R Coppini, C Ferrantini, L Yao, P Fan, M Del Lungo… - Circulation, 2013 - Am Heart Assoc
Background—Hypertrophic cardiomyopathy (HCM), the most common mendelian heart
disorder, remains an orphan of disease-specific pharmacological treatment because of the …
disorder, remains an orphan of disease-specific pharmacological treatment because of the …
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes …
Objectives: This study sought to examine the efficacy of ranolazine versus placebo on
weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 diabetes …
weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 diabetes …
Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors
Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …
Biology of cardiac sodium channel Nav1.5 expression
MB Rook, MM Evers, MA Vos… - Cardiovascular …, 2012 - academic.oup.com
Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …
is an integral membrane protein involved in the initiation and conduction of action potentials …
Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects
CA Remme - The Journal of physiology, 2013 - Wiley Online Library
Over the last two decades, an increasing number of SCN5A mutations have been described
in patients with long QT syndrome type 3 (LQT3), Brugada syndrome,(progressive) …
in patients with long QT syndrome type 3 (LQT3), Brugada syndrome,(progressive) …
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
L Belardinelli, G Liu, C Smith-Maxwell, WQ Wang… - … of Pharmacology and …, 2013 - ASPET
Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and
sodium-dependent calcium overload associated with myocardial ischemia and heart failure …
sodium-dependent calcium overload associated with myocardial ischemia and heart failure …
Targets for therapy in sarcomeric cardiomyopathies
JC Tardiff, L Carrier, DM Bers, C Poggesi… - Cardiovascular …, 2015 - academic.oup.com
To date, no compounds or interventions exist that treat or prevent sarcomeric
cardiomyopathies. Established therapies currently improve the outcome, but novel therapies …
cardiomyopathies. Established therapies currently improve the outcome, but novel therapies …
SCN5A channelopathy: arrhythmia, cardiomyopathy, epilepsy and beyond
CA Remme - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …
for proper electrical conduction within the heart. Both acquired conditions associated with …