The Blood–Brain Barrier: Composition, Properties, and Roles in Brain Health
Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
the body. The blood vessels that vascularize the central nervous system (CNS) possess …
Lactate metabolism, signaling, and function in brain development, synaptic plasticity, angiogenesis, and neurodegenerative diseases
A Wu, D Lee, WC Xiong - International Journal of Molecular Sciences, 2023 - mdpi.com
Neural tissue requires a great metabolic demand despite negligible intrinsic energy stores.
As a result, the central nervous system (CNS) depends upon a continuous influx of …
As a result, the central nervous system (CNS) depends upon a continuous influx of …
Endothelial Unc5B controls blood-brain barrier integrity
Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system
(CNS). Here, we show that the endothelial Unc5B receptor controls BBB integrity by …
(CNS). Here, we show that the endothelial Unc5B receptor controls BBB integrity by …
Netrin-1–engineered endothelial cell exosomes induce the formation of pre-regenerative niche to accelerate peripheral nerve repair
J Huang, J Li, S Li, X Yang, N Huo, Q Chen… - Science …, 2024 - science.org
The formation of vascular niche is pivotal during the early stage of peripheral nerve
regeneration. Nevertheless, the mechanisms of vascular niche in the regulation of …
regeneration. Nevertheless, the mechanisms of vascular niche in the regulation of …
A novel spinal neuron connection for heat sensation
Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …
Astrocytes in the traumatic brain injury: the good and the bad
M Yuan, H Wu - Experimental Neurology, 2022 - Elsevier
Astrocytes control many processes of the nervous system in health and disease, and
respond to injury quickly. Astrocytes produce neuroprotective factors in the injured brain to …
respond to injury quickly. Astrocytes produce neuroprotective factors in the injured brain to …
Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
Background Alzheimer's disease (AD) and osteoporosis are two distinct diseases but often
occur in the same patient. Their relationship remains poorly understood. Studies using …
occur in the same patient. Their relationship remains poorly understood. Studies using …
Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit
Absence of the astrocyte-specific membrane protein MLC1 is responsible for
megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare type of …
megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare type of …
An insight into the microRNAs associated with arteriovenous and cavernous malformations of the brain
Background: Brain arteriovenous malformations (BAVMs) and cerebral cavernous
malformations (CCMs) are rare developmental anomalies of the intracranial vasculature …
malformations (CCMs) are rare developmental anomalies of the intracranial vasculature …
Historical and current perspectives on blood endothelial cell heterogeneity in the brain
RL Matsuoka, LD Buck, KP Vajrala, RE Quick… - Cellular and Molecular …, 2022 - Springer
Dynamic brain activity requires timely communications between the brain parenchyma and
circulating blood. Brain–blood communication is facilitated by intricate networks of brain …
circulating blood. Brain–blood communication is facilitated by intricate networks of brain …