The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Background Pharmacological treatment of CNS diseases is limited due to the presence of
the blood-brain barrier (BBB). Recent years showed significant advancement in the field of …

Objective: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields
(PEFs) to permeabilize tumor tissue; this results in changes in electrical properties …

Objective: Tissue electroporation is achieved by applying a series of electric pulses to
destabilize cell membranes within the target tissue. The treatment volume is dictated by the …

Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic
(ie, theranostic) potencies in translational oncology, and some agents have been further …

The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents
to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we …

The blood–brain barrier (BBB) constitutes a major obstacle to effective delivery of drugs to
the brain. Recent technological advances have led to improvements in brain-targeted drug …

The blood–brain barrier (BBB) is a major hurdle for the treatment of central nervous system
disorders, limiting passage of both small and large therapeutic agents from the blood stream …

High-voltage pulsed electric fields (HV-PEF) delivered with invasive needle electrodes for
electroporation applications is known to induce off-target blood–brain barrier (BBB) …