Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …
ejection fraction (HFpEF), the most common form of heart failure among older individuals …
Sex differences in myocardial and vascular aging
It is well known that cardiovascular disease manifests differently in women and men. The
underlying causes of these differences during the aging lifespan are less well understood …
underlying causes of these differences during the aging lifespan are less well understood …
Determining a multimodal aging clock in a cohort of Chinese women
Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …
to address the unmet needs of the global aging population. However, to successfully do so …
Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention
G Benincasa, E Coscioni, C Napoli - Biochemical Pharmacology, 2022 - Elsevier
One of the major challenges of cardiovascular primary prevention approach is the absence
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice
Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …
Evaluation of the interaction of sex hormones and cardiovascular function and health
MMA Willemars, M Nabben, JAJ Verdonschot… - Current heart failure …, 2022 - Springer
Abstract Purpose of Review Sex hormones drive development and function of reproductive
organs or the development of secondary sex characteristics but their effects on the …
organs or the development of secondary sex characteristics but their effects on the …
Best practices to promote rigor and reproducibility in the era of sex-inclusive research
JW Rich-Edwards, DL Maney - Elife, 2023 - elifesciences.org
To enhance inclusivity and rigor, many funding agencies and journals now mandate the
inclusion of females as well as males in biomedical studies. These mandates have …
inclusion of females as well as males in biomedical studies. These mandates have …
Genetic, molecular, and cellular determinants of sex-specific cardiovascular traits
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic,
molecular, and cellular underpinnings of these differences are not well understood. A …
molecular, and cellular underpinnings of these differences are not well understood. A …
The sex-dependent response to psychosocial stress and ischaemic heart disease
TJ Helman, JP Headrick, NJC Stapelberg… - Frontiers in …, 2023 - frontiersin.org
Stress is an important risk factor for modern chronic diseases, with distinct influences in
males and females. The sex specificity of the mammalian stress response contributes to the …
males and females. The sex specificity of the mammalian stress response contributes to the …
[HTML][HTML] Impact of air pollution on cardiovascular aging
The world population is aging rapidly, and by some estimates, the number of people older
than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects …
than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects …