Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Primary ciliary dyskinesia is a genetically heterogeneous disorder of motile cilia. Most of the
disease-causing mutations identified to date involve the heavy (dynein axonemal heavy …

Primary ciliary dyskinesia (PCD; MIM 242650) is an autosomal recessive disorder of ciliary
dysfunction with extensive genetic heterogeneity. PCD is characterized by bronchiectasis …

Cilia, hair-like structures extending from the cell membrane, perform diverse biological
functions. Primary (genetic) defects in the structure and function of sensory and motile cilia …

Kartagener syndrome (KS) is a trilogy of symptoms (nasal polyps, bronchiectasis, and situs
inversus totalis) that is associated with ultrastructural anomalies of cilia of epithelial cells …

Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by perturbed or
absent beating of motile cilia, which is referred to as Kartagener syndrome (KS) when …

Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by
a highly developed innate defense system. Physiologically regulated epithelial ion and …

Thioredoxins belong to a large family of enzymatic proteins that function as general protein
disulfide reductases, therefore participating in several cellular processes via redox-mediated …

The forkhead (Fox) gene family comprises a diverse group of 'winged-helix'transcription
factors that play important roles in development, metabolism, cancer and aging. Recently …

Background Ciliated cells play a central role in cleansing the airways of inhaled
contaminants. They are derived from basal cells that include the airway stem/progenitor …