Direct oral anticoagulants: evidence and unresolved issues

N Chan, M Sobieraj-Teague, JW Eikelboom - The Lancet, 2020 - thelancet.com
Currently licenced direct oral anticoagulants selectively target thrombin (eg, dabigatran) or
coagulation factor Xa (eg, apixaban, betrixaban, edoxaban, and rivaroxaban). Designed to …

[HTML][HTML] Old and new oral anticoagulants: food, herbal medicines and drug interactions

A Di Minno, B Frigerio, G Spadarella, A Ravani… - Blood reviews, 2017 - Elsevier
The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists
(VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important …

Restarting anticoagulant treatment after intracranial hemorrhage in patients with atrial fibrillation and the impact on recurrent stroke, mortality, and bleeding: a …

PB Nielsen, TB Larsen, F Skjøth, A Gorst-Rasmussen… - Circulation, 2015 - Am Heart Assoc
Background—Intracranial hemorrhage is the most feared complication of oral anticoagulant
treatment. The optimal treatment option for patients with atrial fibrillation who survive an …

Evolving treatments for arterial and venous thrombosis: role of the direct oral anticoagulants

NC Chan, JW Eikelboom, JI Weitz - Circulation research, 2016 - Am Heart Assoc
The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant
therapy and have replaced the vitamin K antagonists as the preferred treatment for many …

Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin

R Kurogi, K Nishimura, M Nakai, A Kada, S Kamitani… - Neurology, 2018 - AAN Enterprises
Objectives This cross-sectional survey explored the characteristics and outcomes of direct
oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by …

Updates in anticoagulation therapy monitoring

HL McRae, L Militello, MA Refaai - Biomedicines, 2021 - mdpi.com
In the past six decades, heparin and warfarin were the primary anticoagulants prescribed for
treatment and prophylaxis of venous thromboembolism worldwide. This has been …

Clinically relevant drug interactions between newer antidepressants and oral anticoagulants

E Spina, MA Barbieri, G Cicala, A Bruno… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: This is a review of the drug interactions (DIs) between newer antidepressants
and oral anticoagulants (OACs): vitamin K antagonists (VKAs) and direct-acting OACs …

How to choose appropriate direct oral anticoagulant for patient with nonvalvular atrial fibrillation

JK Schaefer, RD McBane, WE Wysokinski - Annals of hematology, 2016 - Springer
The novel oral anticoagulants or direct oral anticoagulants (DOAC) are becoming more
common in clinical practice for the prevention of stroke in non-valvular atrial fibrillation …

Simple decision-making between a vitamin K antagonist and a non-vitamin K antagonist oral anticoagulant: using the SAMe-TT2R2 score

M Proietti, GYH Lip - European Heart Journal-Cardiovascular …, 2015 - academic.oup.com
Stroke prevention with oral anticoagulation (OAC) is central to the modern management of
atrial fibrillation (AF) patients. 1 For many years, vitamin K antagonists (VKAs, eg warfarin) …

STOPP/START anti-aggregation and anticoagulation alerts in atrial fibrillation

F Salis, A Palimodde, S Rundeddu… - Current Vascular …, 2023 - ingentaconnect.com
Background: Atrial Fibrillation (AF) is common in the elderly. A key component of AF
management is Oral Anticoagulant Therapy (OAT), consisting of Vitamin K Antagonists …