Simple Summary Heat-shock proteins (HSPs) are molecular chaperones overexpressed in
tumor cells and are necessary for their survival. In leukemia and lymphoma, HSPs have …

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report
that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that …

The search for molecules to be targeted that are involved in apoptosis resistance/increased
survival and pathogenesis of onco-hematological malignancies is ongoing since these …

Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …

Background Recent studies have shown that the classic hypoglycemic drug metformin
inhibits tumor growth; however, the underlying mechanism remains unclear. We previously …

Despite recent advances, there remains a significant unmet need for the development of
new targeted therapies for triple-negative breast cancer (TNBC). Although the heat shock …

Background Ion channels are emerging as promising oncological targets. The potassium
channels Kv1. 3 and IKCa are highly expressed in the plasma membrane and mitochondria …

The bone marrow microenvironment promotes proliferation and drug resistance in chronic
lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear …

The implantation of good-quality embryos to the receptive endometrium is essential for
successful live birth through in vitro fertilization (IVF). The higher the quality of embryos, the …

Background. Sepsis, which could cause a systemic inflammatory response, is a life‐
threatening disease with a high morbidity and mortality rate. There is evidence that brain …