Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

The metabolic syndrome (MS) represents a cluster of cardiovascular (CV) risk factors
associated to CV disease and type 2 diabetes. It is still under debate whether MS is a mere …

The prevalence of the metabolic syndrome has increased worldwide over the past few
years. Sympathetic nervous system overactivity is a key mechanism leading to hypertension …

Uncovering the biological role of nuclear receptor peroxisome proliferator-activated
receptors (PPARs) has greatly advanced our knowledge of the transcriptional control of …

Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone
secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora …

169 OBESITY, INFLAMMATION AND ENDOTHELIAL DYSFUNCTION M. IANTORNO1, U.
CAMPIA2, N. DI DANIELE3, S. NISTICÒ4, GB FORLEO3, C. C Page 1 PROOF JOURNAL OF …

A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …

Diabetes is a worldwide health issue closely associated with cardiovascular events. Given
the pandemic of obesity, the identification of the basic underpinnings of vascular disease is …

The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3
position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of …

Ghrelin is an acylated peptidyl gastric hormone acting on the pituitary and hypothalamus to
stimulate appetite, adiposity, and growth hormone release, through activation of growth …