Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy
M Prokocimer, A Molchadsky… - Blood, The Journal of the …, 2017 - ashpublications.org
The heterogeneous nature of acute myeloid leukemia (AML) and its poor prognosis
necessitate therapeutic improvement. Current advances in AML research yield important …
necessitate therapeutic improvement. Current advances in AML research yield important …
The long and the short of it: the MDM4 tail so far
S Haupt, JO Mejía-Hernández… - Journal of molecular …, 2019 - academic.oup.com
The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Cancer Genome Atlas Research … - New England Journal of …, 2013 - Mass Medical Soc
Background Many mutations that contribute to the pathogenesis of acute myeloid leukemia
(AML) are undefined. The relationships between patterns of mutations and epigenetic …
(AML) are undefined. The relationships between patterns of mutations and epigenetic …
Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations
Background Extramedullary manifestations (EM) are rare in acute myeloid leukemia (AML)
and their impact on clinical outcomes is controversially discussed. Methods We …
and their impact on clinical outcomes is controversially discussed. Methods We …
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and
oncogenes, involving distinct genes in adults and children. While certain mutations have …
oncogenes, involving distinct genes in adults and children. While certain mutations have …
[HTML][HTML] MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer
(NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high …
(NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high …
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
Background MicroRNAs (miRNAs) bind to mRNAs and target them for translational inhibition
or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the …
or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the …
Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma
J Hudson, E Duncavage, A Tamburrino… - … and molecular pathology, 2013 - Elsevier
MicroRNAs are a primordial mechanism of gene expression control that appear to be crucial
to cellular development and may play an important role in tumor development. Much is …
to cellular development and may play an important role in tumor development. Much is …
Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia
F Zhi, X Cao, X Xie, B Wang, W Dong, W Gu, Y Ling… - PloS one, 2013 - journals.plos.org
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The disease is
characterized by various cytogenetic and molecular abnormalities with distinct prognoses …
characterized by various cytogenetic and molecular abnormalities with distinct prognoses …
MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame
P Mandke, N Wyatt, J Fraser, B Bates, SJ Berberich… - 2012 - journals.plos.org
Background MDM4, also called MDMX or HDMX in humans, is an important negative
regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers …
regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers …