Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Electrophysiological studies of the human heart face the fundamental challenge that
experimental data can be acquired only from patients with underlying heart disease …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Fast calcium transients (< 10 ms) remain difficult to analyse in cellular microdomains, yet
they can modulate key cellular events such as trafficking, local ATP production by …

Chronic atrial fibrillation (AF) is a complex disease with underlying changes in
electrophysiology, calcium signaling and the structure of atrial myocytes. How these …

In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to
decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to …

Using optical and electrical methods, we document that diffusion in the cytoplasm of BL6
murine cardiomyocytes becomes restricted> 20-fold as molecular weight increases from 30 …

Duchenne muscular dystrophy (DMD), induced by mutations in the gene encoding for the
cytoskeletal protein dystrophin, is an inherited disease characterized by progressive muscle …