The subthalamic corticotropin-releasing hormone neurons mediate adaptive REM-sleep responses to threat

YT Tseng, B Zhao, S Chen, J Ye, J Liu, L Liang, H Ding… - Neuron, 2022 - cell.com
When an animal faces a threatening situation while asleep, rapid arousal is the essential
prerequisite for an adequate response. Here, we find that predator stimuli induce immediate …

Turning the′ Tides on neuropsychiatric diseases: the role of peptides in the prefrontal cortex

DF Brockway, NA Crowley - Frontiers in Behavioral Neuroscience, 2020 - frontiersin.org
Recent advancements in technology have enabled researchers to probe the brain with the
greater region, cell, and receptor specificity. These developments have allowed for a more …

Corticotropin‐releasing factor signaling and its potential role in the prefrontal cortex‐dependent regulation of anxiety

X Yang, F Geng - Journal of Neuroscience Research, 2023 - Wiley Online Library
A large body of literature has highlighted the significance of the corticotropin‐releasing
factor (CRF) system in the regulation of neuropsychiatric diseases. Anxiety disorders are …

Prefrontal cortex corticotropin-releasing factor neurons control behavioral style selection under challenging situations

P Chen, S Lou, ZH Huang, Z Wang, QH Shan, Y Wang… - Neuron, 2020 - cell.com
In response to stressors, individuals adopt different behavioral styles, which are essential for
survival and form the basis of differential susceptibility to stress-related disorders …

Corticotropin-releasing factor in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context

AL Schreiber, YL Lu, BB Baynes, HN Richardson… - …, 2017 - Elsevier
Post-traumatic stress disorder (PTSD) affects 7.7 million Americans. One diagnostic criterion
for PTSD is avoidance of stimuli that are related to the traumatic stress. Using a predator …

Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: role …

TT Miguel, KS Gomes, RL Nunes-de-Souza - Hormones and behavior, 2014 - Elsevier
The medial prefrontal cortex (mPFC) and the neuropeptide corticotropin-releasing factor
(CRF) have recently been receiving more attention from those interested in the neurobiology …

CRF receptor type 1 (but not type 2) located within the amygdala plays a role in the modulation of anxiety in mice exposed to the elevated plus maze

AC Cipriano, KS Gomes, RL Nunes-de-Souza - Hormones and behavior, 2016 - Elsevier
The amygdala (Amy) is an important center that processes threatening stimuli. Among the
neurotransmitters implicated in the control of emotional states, the corticotrophin releasing …

Neurotensin 1 receptor in the prelimbic cortex regulates anxiety-like behavior in rats

B Li, LL Chang, K Xi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
The central neurotensin system has been implicated in reward, memory processes, also in
the regulation of anxiety. However, the neural substrates where neurotensin acts to regulate …

Antagonizing serotonin 2A (5-HT2A) receptors attenuates methamphetamine-induced reward and blocks methamphetamine-induced anxiety-like behaviors in adult …

JT Madden, NC Reyna, NS Pentkowski - Drug and Alcohol Dependence, 2020 - Elsevier
Background Methamphetamine is a highly addictive and abused psychostimulant.
Symptoms of methamphetamine withdrawal including drug craving and anxiety that can …

Mechanisms underlying the rapid-acting antidepressant-like effects of neuropeptide VGF (non-acronymic) C-terminal peptide TLQP-62

D Lv, Y Chen, M Shen, X Liu, Y Zhang, J Xu… - Neuropharmacology, 2018 - Elsevier
Previous studies have revealed that neuropeptide VGF (non-acronymic) C-terminal peptide
TLQP-62 rapidly activates brain-derived neurotrophic factor (BDNF)/tropomyosin receptor …