The “phenylpropenoids” are a well-known set of naturally occurring compounds obtained
mainly from plant sources. 1, 2 Of this group, the generalized 2-propenylbenzenes 1 and 1 …

Highlights•We described a detailed account of all the advances on podophyllotoxin
derivatives targeting tubulin from 2017 and 2022.•This review comprehensively summarized …

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using
microwave-assisted three-component reactions is reported in this study. Novel …

An expeditious microwave-assisted one-pot synthesis of new cytotoxic phenanthrene fused-
tetrahydrodibenzo-acridinones has been successfully accomplished. This protocol offers …

Cytotoxic constituents of the terrestrial plant Bridelia ferruginea were isolated using
bioactivity-guided fractionation, which revealed the presence of the previously known …

The aim of this study was the synthesis and lead structure selection of a best anti-leukemic
agent from a library of aza-podophyllotoxin analogues (APTs). To this end, we report a …

Podophyllotoxin (PT) and its clinically used analogues are known to be powerful antitumour
agents. These compounds contain a trans fused strained γ-lactone system, a feature that …

A series of 12 polysubstituted pyrrolo [3, 4-b] pyridin-5-ones were synthesized via a one-pot
cascade process (Ugi–3CR/aza Diels-Alder/N-acylation/decarboxylation/dehydration) and …

An efficient method is introduced based on the copper (II) acetate catalyzed one-pot
multicomponent synthesis of novel chromeno [4, 3-b] pyrano [3, 4-e] pyridine-6, 8-dione …

Abstract 4H-Pyrans (4H-Pys) and 1, 4-dihydropyridines (1, 4-DHPs) are important classes of
heterocyclic scaffolds in medicinal chemistry. Herein, an indium (III)-catalyzed one-pot …