Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Intranasal oxytocin: myths and delusions

G Leng, M Ludwig - Biological psychiatry, 2016 - Elsevier
Despite widespread reports that intranasal application of oxytocin has a variety of behavioral
effects, very little of the huge amounts applied intranasally appears to reach the …

Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans

R Hurlemann, A Patin, OA Onur, MX Cohen… - Journal of …, 2010 - Soc Neuroscience
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans
with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the …

Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight

SE Taylor, LC Klein, BP Lewis, TL Gruenewald… - 2002 - direct.mit.edu
Background The fight-or-flight response is generally regarded as the prototypic human
response to stress. First described by Walter Cannon in 1932, the fightor-flight response is …

The oxytocin receptor system: structure, function, and regulation

G Gimpl, F Fahrenholz - Physiological reviews, 2001 - journals.physiology.org
The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in
all vertebrates at several levels. The major site of OT gene expression is the magnocellular …

Why does social exclusion hurt? The relationship between social and physical pain.

G MacDonald, MR Leary - Psychological bulletin, 2005 - psycnet.apa.org
The authors forward the hypothesis that social exclusion is experienced as painful because
reactions to rejection are mediated by aspects of the physical pain system. The authors …

Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior

HE Ross, LJ Young - Frontiers in neuroendocrinology, 2009 - Elsevier
Oxytocin is produced in the hypothalamus and released into the circulation through the
neurohypophyseal system. Peripherally released oxytocin facilitates parturition and milk …

Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact

R Feldman, I Gordon, I Schneiderman… - …, 2010 - Elsevier
Animal studies have demonstrated that the neuropeptide oxytocin (OT) plays a critical role in
processes of parent–infant bonding through mechanisms of early parental care, particularly …

The neurobiology of attachment

TR Insel, LJ Young - Nature Reviews Neuroscience, 2001 - nature.com
It is difficult to think of any behavioural process that is more intrinsically important to us than
attachment. Feeding, sleeping and locomotion are all necessary for survival, but humans …

Oxytocin may mediate the benefits of positive social interaction and emotions

K Uvnäs-Moberg - Psychoneuroendocrinology, 1998 - Elsevier
During breastfeeding or suckling, maternal oxytocin levels are raised by somatosensory
stimulation. Oxytocin may, however, also be released by nonnoxious stimuli such as touch …