Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …

A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane
integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial …

The apoptosome is a platform that activates apical procaspases in response to intrinsic cell
death signals. Biochemical and structural studies in the past two decades have extended …

Recent work on the initial switches that trigger cell death has revealed surprising inventions
of nature that ensure the ordered suicide of a cell that has been selected for demise …

Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …

The first proapoptotic caspase, CED-3, was cloned from Caenorhabditis elegans in 1993
and shown to be essential for the developmental death of all somatic cells. Following the …

In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …

Apaf-1-like molecules assemble into a ring-like platform known as the apoptosome. This cell
death platform then activates procaspases in the intrinsic cell death pathway. In this review …

Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many
forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a …