[HTML][HTML] Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management
Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and
hematologic malignancies, but its clinical application is hampered by life-threatening …
hematologic malignancies, but its clinical application is hampered by life-threatening …
Melatonin as an antioxidant: under promises but over delivers
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …
number of circumstances. It achieves this action via a variety of means: direct detoxification …
Melatonin in cancer treatment: current knowledge and future opportunities
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …
experimental studies have documented that melatonin could inhibit different types of cancer …
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …
Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …
of cancer, but their clinical use is associated with severe and potentially life-threatening …
Phytomelatonin: assisting plants to survive and thrive
This review summarizes the advances that have been made in terms of the identified
functions of melatonin in plants. Melatonin is an endogenously-produced molecule in all …
functions of melatonin in plants. Melatonin is an endogenously-produced molecule in all …
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
D Liu, Z Ma, S Di, Y Yang, J Yang, L Xu… - Free Radical Biology …, 2018 - Elsevier
Doxorubicin (DOX) is a highly effective anticancer anthracycline drug, but its side effects at
the level of the heart has limited its widespread clinical application. Melatonin is a …
the level of the heart has limited its widespread clinical application. Melatonin is a …
SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin
H Pi, S Xu, RJ Reiter, P Guo, L Zhang, Y Li, M Li… - Autophagy, 2015 - Taylor & Francis
Cadmium is one of the most toxic metal compounds found in the environment. It is well
established that Cd induces hepatotoxicity in humans and multiple animal models …
established that Cd induces hepatotoxicity in humans and multiple animal models …
Updates in anthracycline-mediated cardiotoxicity
CG Nebigil, L Désaubry - Frontiers in Pharmacology, 2018 - frontiersin.org
Cardiotoxicity is one of the main adverse effects of chemotheraphy, affecting the completion
of cancer therapies and the short-and long-term quality of life. Anthracyclines are currently …
of cancer therapies and the short-and long-term quality of life. Anthracyclines are currently …