Arginine “magic”: Guanidinium like-charge ion pairing from aqueous salts to cell penetrating peptides
It is a textbook knowledge that charges of the same polarity repel each other. For two
monovalent ions in the gas phase at a close contact this repulsive interaction amounts to …
monovalent ions in the gas phase at a close contact this repulsive interaction amounts to …
The rational design of cell-penetrating peptides for application in delivery systems
Z Kang, G Ding, Z Meng, Q Meng - Peptides, 2019 - Elsevier
Cell penetrating peptides (CPPs) play a crucial role in the transportation of bioactive
molecules. Although CPPs have been used widely in various delivery systems, further …
molecules. Although CPPs have been used widely in various delivery systems, further …
Polyarginine interacts more strongly and cooperatively than polylysine with phospholipid bilayers
The interactions of two highly positively charged short peptide sequences with negatively
charged lipid bilayers were explored by fluorescence binding assays and all-atom molecular …
charged lipid bilayers were explored by fluorescence binding assays and all-atom molecular …
Ionic strength and solution composition dictate the adsorption of cell-penetrating peptides onto phosphatidylcholine membranes
Adsorption of arginine-rich positively charged peptides onto neutral zwitterionic
phosphocholine (PC) bilayers is a key step in the translocation of those potent cell …
phosphocholine (PC) bilayers is a key step in the translocation of those potent cell …
Self-association of a highly charged arginine-rich cell-penetrating peptide
Small-angle X-ray scattering (SAXS) measurements reveal a striking difference in
intermolecular interactions between two short highly charged peptides—deca-arginine …
intermolecular interactions between two short highly charged peptides—deca-arginine …
Neurobiochemical characteristics of arginine-rich peptides explain their potential therapeutic efficacy in neurodegenerative diseases
S Eskandari, A Rezayof, SM Asghari, S Hashemizadeh - Neuropeptides, 2023 - Elsevier
Neurodegenerative diseases, including Alzheimer̕ s disease (AD), Parkinson̕ s disease
(PD), Huntington̕ s disease (HD), and Amyotrophic Lateral Sclerosis (ALS) require special …
(PD), Huntington̕ s disease (HD), and Amyotrophic Lateral Sclerosis (ALS) require special …
An Amphiphilic Sulfonatocalix [5] arene as an Activator for Membrane Transport of Lysine‐rich Peptides and Proteins
YC Pan, A Barba‐Bon, HW Tian, F Ding… - Angewandte Chemie …, 2021 - Wiley Online Library
Lysine (K) is an important target residue for protein and peptide delivery across membranes.
K is the most frequently exposed residue in proteins, leading to high demand for the …
K is the most frequently exposed residue in proteins, leading to high demand for the …
Effect of arginine-rich cell penetrating peptides on membrane pore formation and life-times: a molecular simulation study
The molecular basis for the effectiveness of arginine-rich cell penetrating peptides
(ARCPPs) traversing a cell membrane barrier is not well established. The fact that a …
(ARCPPs) traversing a cell membrane barrier is not well established. The fact that a …
Adsorption/Desorption of Cationic-Hydrophobic Peptides on Zwitterionic Lipid Bilayer Is Associated with the Possibility of Proton Transfer
L Pašalić, A Jakas, B Pem, D Bakarić - Antibiotics, 2023 - mdpi.com
Cell-penetrating peptides (CPPs) are short peptides built up from dominantly cationic and
hydrophobic amino acid residues with a distinguished ability to pass through the cell …
hydrophobic amino acid residues with a distinguished ability to pass through the cell …
Why do polyarginines adsorb at neutral phospholipid bilayers and polylysines do not? An insight from density functional theory calculations and molecular dynamics …
Adsorption of cell-penetrating peptides (CPPs) at cellular membranes is the first and
necessary step for their subsequent translocation across cellular membranes into the …
necessary step for their subsequent translocation across cellular membranes into the …