Metabolic reprogramming in cholangiocarcinoma

C Raggi, ML Taddei, C Rae, C Braconi, F Marra - Journal of hepatology, 2022 - Elsevier
Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

Protein analysis by shotgun/bottom-up proteomics

Y Zhang, BR Fonslow, B Shan, MC Baek… - Chemical …, 2013 - ACS Publications
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Glycosylation: a hallmark of cancer?

BN Vajaria, PS Patel - Glycoconjugate journal, 2017 - Springer
The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Cell surface protein glycosylation in cancer

MN Christiansen, J Chik, L Lee, M Anugraham… - …, 2014 - Wiley Online Library
Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

[HTML][HTML] Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis

K Ščupáková, OT Adelaja, B Balluff, V Ayyappan… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND. Although aberrant glycosylation is recognized as a hallmark of cancer,
glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While …

[HTML][HTML] Integrated proteomic and glycoproteomic characterization of human high-grade serous ovarian carcinoma

Y Hu, J Pan, P Shah, M Ao, SN Thomas, Y Liu, L Chen… - Cell reports, 2020 - cell.com
Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …

[HTML][HTML] CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer

KE Craven, Y Gökmen-Polar, SS Badve - Scientific Reports, 2021 - nature.com
Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple
Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular …

[HTML][HTML] Imaging mass spectrometry and lectin analysis of N-linked glycans in carbohydrate antigen–defined pancreatic cancer tissues

CT McDowell, Z Klamer, J Hall, CA West… - Molecular & Cellular …, 2021 - ASBMB
The early detection of pancreatic ductal adenocarcinoma (PDAC) is a complex clinical
obstacle yet is key to improving the overall likelihood of patient survival. Current and …

Capillary electrophoresis separations of glycans

G Lu, CL Crihfield, S Gattu, LM Veltri… - Chemical …, 2018 - ACS Publications
Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …