Genetic variants causing G6PD deficiency: Clinical and biochemical data support new WHO classification

C Nannelli, A Bosman, J Cunningham… - British Journal of …, 2023 - Wiley Online Library
Summary Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency in erythrocytes causes
acute haemolytic anaemia upon exposure to fava beans, drugs, or infection; and it …

A review of the current status of G6PD deficiency testing to guide radical cure treatment for vivax malaria

A Sadhewa, S Cassidy-Seyoum, S Acharya, A Devine… - Pathogens, 2023 - mdpi.com
Plasmodium vivax malaria continues to cause a significant burden of disease in the Asia-
Pacific, the Horn of Africa, and the Americas. In addition to schizontocidal treatment, the 8 …

Operational feasibility of Plasmodium vivax radical cure with tafenoquine or primaquine following point-of-care, quantitative glucose-6-phosphate dehydrogenase …

M Brito, R Rufatto, F Murta, V Sampaio… - The Lancet Global …, 2024 - thelancet.com
Background To achieve malaria elimination, Brazil must implement Plasmodium vivax
radical cure. We aimed to investigate the operational feasibility of point-of-care, quantitative …

Field assessment of the operating procedures of a semi-quantitative G6PD Biosensor to improve repeatability of routine testing

A Sadhewa, A Chaudhary, LV Panggalo, A Rumaseb… - Plos one, 2024 - journals.plos.org
In remote communities, diagnosis of G6PD deficiency is challenging. We assessed the
impact of modified test procedures and delayed testing for the point-of-care diagnostic …

Potentially pathogenic and pathogenic G6PD variants

L Luzzatto, C Nannelli, R Notaro - The American Journal of Human …, 2023 - cell.com
In their interesting and comprehensive paper in the February 2, 2023 issue of this journal,
Geck et al. 1 have illustrated several aspects of genetic variation at the X-linked G6PD locus …

Field evaluation of a novel semi-quantitative point-of-care diagnostic for G6PD deficiency in Indonesia

A Sadhewa, LV Panggalo, I Nanine, RN Price… - Plos one, 2024 - journals.plos.org
Background The WHO recommends routine testing of G6PD activity to guide radical cure in
patients with Plasmodium vivax malaria. Females may have intermediate G6PD enzyme …

Simultaneous detection of G6PD mutations using SNPscan in a multiethnic minority area of Southwestern China

H Wei, C Wang, W Huang, L He, Y Liu, H Huang… - Frontiers in …, 2023 - frontiersin.org
Objectives: Baise, a multiethnic inhabited area of southwestern China, is a historical malaria-
endemic area with a high prevalence of G6PD deficiency. However, few studies of G6PD …

Substitution of arginine 219 by glycine compromises stability, dimerization, and catalytic activity in a G6PD mutant

O Zgheib, K Chamchoy, T Nouspikel, JL Blouin… - Communications …, 2023 - nature.com
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most
common enzymopathies in humans, present in approximately half a billion people …

Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province

HF Liang, YB Cao, F Lin, YK Yang, YW Liao… - Frontiers in …, 2024 - frontiersin.org
Objectives: The prevalence of G6PD deficiency has not been reported in Yangjiang, a
western city in Guangdong province. This study aims to investigate the molecular …

Plasmodium vivax Malaria and G6PD Testing

B Ley, L Luzzatto - Pathogens, 2023 - mdpi.com
Early malaria investigators were certainly correct in classifying the species falciparum and
the species vivax as belonging to the same genus, Plasmodium. Both are intraerythrocytic in …