Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

Monocytes undergo phenotypic and functional changes in response to inflammatory cues,
but the molecular signals that drive different monocyte states remain largely undefined. We …

The accumulation of DNA and nuclear components in blood and their recognition by
autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus …

Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Photosensitivity to ultraviolet (UV) light affects up to∼ 80% of lupus patients. Sunlight
exposure can exacerbate local as well as systemic manifestations of lupus, including …

Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …

The first description of a new form of neutrophil cell death distinct from that of apoptosis or
necrosis was discovered in 2004 and coined neutrophil extracellular traps “(NETs)” or …

The glomerular crescent: triggers, evolution, resolution, an... : Current Opinion in Nephrology
and Hypertension The glomerular crescent: triggers, evolution, resolution, and implications for …