The Loxosceles genus spiders (the brown spiders) are encountered in all the continents,
and the clinical manifestations following spider bites include skin necrosis with gravitational …

Spiders of the genus Loxosceles, popularly known as Brown spiders, are considered a
serious public health issue, especially in regions of hot or temperate climates, such as parts …

Brown spiders are venomous arthropods that use their venom for predation and defense. In
humans, bites of these animals provoke injuries including dermonecrosis with gravitational …

Envenoming resulting from Loxosceles spider bites (loxoscelism) is a recognized public
health problem in Brazil. However, the pathophysiology of loxoscelism caused by L. similis …

Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in
Loxosceles spider venoms and have been described in some strains of pathogenic …

Abstract Loxosceles spp.(Araneae, Sicariidae), known as brown spiders, are distributed in
temperate and tropical regions worldwide. Accidents caused by these spiders are known as …

Loxoscelism refers to the clinical symptoms that develop after brown spider bites. Brown
spider venoms contain several phospholipase‐D isoforms, which are the main toxins …

Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the
development of a dermonecrotic lesion, strong inflammatory response, the production of pro …

Brown spider envenomation results in dermonecrosis, characterized by an intense
inflammatory reaction. The principal toxins of brown spider venoms are phospholipase-D …

Spiders of Loxosceles genus are widely distributed and their venoms contain
phospholipases D (PLDs), which degrade phospholipids and trigger inflammatory …