At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Improvements in the gene transfer vectors used in therapeutic trials have led to substantial
clinical successes in patients with serious genetic conditions, such as immunodeficiency …

Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …

We have entered a new era in HIV prevention whereby priorities have expanded from
biomedical discovery to include implementation, effectiveness, and the effect of combination …

Therapeutic genome editing technology has been widely used as a powerful tool for directly
correcting genetic mutations in target pathological tissues and cells to cure of diseases. The …

Antiretroviral therapy (ART) has rendered HIV-1 infection a manageable illness for those
with access to treatment. However, ART does not lead to viral eradication owing to the …

In Part I of this Review, we introduced recent advances in gene delivery technologies and
explained how they have powered some of the current human gene therapy applications. In …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

Adenoviral, retroviral/lentiviral, adeno-associated viral, and herpesviral vectors are the major
viral vectors used in gene therapy. Compared with non-viral methods, viruses are highly …