The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Importance Computational psychiatry studies have investigated how reinforcement learning
may be different in individuals with mood and anxiety disorders compared with control …

Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Importance Major depressive disorder is prevalent and impairing. Parsing
neurocomputational substrates of reinforcement learning in individuals with depression may …

Importance Dysfunctional reward processing is a leading candidate mechanism for the
development of certain depressive symptoms, such as anhedonia. However, to our …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

The cognitive model of depression has significantly influenced the understanding of
distorted cognitive processes in major depression; however, this model's conception of …

Anhedonia is a key symptom of major depressive disorder (MDD) and comprises
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …