Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation

MD Vandermeulen, MC Lorenz, PJ Cullen - Genetics, 2024 - academic.oup.com
Eukaryotic organisms are composed of different cell types with defined shapes and
functions. Specific cell types are produced by the process of cell differentiation, which is …

Turnover and bypass of p21-activated kinase during Cdc42-dependent MAPK signaling in yeast

B González, M Mirzaei, S Basu, AN Pujari… - Journal of Biological …, 2023 - ASBMB
Mitogen-activated protein kinase (MAPK) pathways regulate multiple cellular behaviors,
including the response to stress and cell differentiation, and are highly conserved across …

Modulators of MAPK pathway activity during filamentous growth in Saccharomyces cerevisiae

AN Pujari, PJ Cullen - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
Mitogen-activated protein kinase (MAPK) pathways control the response to intrinsic and
extrinsic stimuli. In the budding yeast Saccharomyces cerevisiae, cells undergo filamentous …

Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway

B González, PJ Cullen - Journal of Cell Biology, 2022 - rupress.org
Rho GTPases are central regulators of cell polarity and signaling. How Rho GTPases are
directed to function in certain settings remains unclear. Here, we show the protein levels of …

Hsp90 mediates the crosstalk between galactose metabolism and cell morphology pathways in yeast

RK Gopinath, JY Leu - Current genetics, 2017 - Springer
Galactose metabolism in the yeast Saccharomyces cerevisiae is carried out by a specialized
GAL pathway consisting of structural and regulatory proteins. It is known that cells with …

Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway

S Basu, B González, B Li, G Kimble… - Molecular biology of …, 2020 - Am Soc Cell Biol
Ras homology (Rho) GTPases regulate cell polarity and signal transduction pathways to
control morphogenetic responses in different settings. In yeast, the Rho GTPase Cdc42p …

Aggregate filamentous growth responses in yeast

J Chow, HM Dionne, A Prabhakar, A Mehrotra… - Msphere, 2019 - Am Soc Microbiol
Many fungal species, including pathogens, undergo a morphogenetic response called
filamentous growth, where cells differentiate into a specialized cell type to promote nutrient …

Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans

D Saraswat, R Kumar, T Pande… - Molecular …, 2016 - Wiley Online Library
Temperature is a potent inducer of fungal dimorphism. Multiple signalling pathways control
the response to growth at high temperature, but the sensors that regulate these pathways …

Scaffold protein Ahk1, which associates with Hkr1, Sho1, Ste11, and Pbs2, inhibits cross talk signaling from the Hkr1 osmosensor to the Kss1 mitogen-activated …

A Nishimura, K Yamamoto, M Oyama… - … and cellular biology, 2016 - Am Soc Microbiol
In the budding yeast Saccharomyces cerevisiae, osmostress activates the Hog1 mitogen-
activated protein kinase (MAPK), which regulates diverse osmoadaptive responses. Hkr1 is …

Growth hormone releasing hormone in the unfolded protein response context

N Barabutis - Endocrine, 2020 - Springer
Abstract The effects of Growth Hormone Releasing Hormone in human pathophysiology are
not limited to those mediated by the Growth Hormone Releasing Hormone–Growth …