Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix
interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin
signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well …

Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration
downstream of integrin engagement with the extracellular matrix. In this review, we focus on …

Engagement of integrin receptors with extracellular ligands gives rise to the formation of
complex multiprotein structures that link the ECM to the cytoplasmic actin cytoskeleton …

Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans
and Drosophila melanogaster, function as critical upstream regulators of Rac during …

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes …

The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII,
dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic …

Diverse cellular processes are carried out by distinct integrin-mediated adhesions. Cell
spreading and migration are driven by focal complexes; robust adhesion to the extracellular …