Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?

S Merlo, SF Spampinato… - CNS neuroscience & …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is characterized by extensive neurodegeneration and
inflammation in selective brain areas, linked to severely disabling cognitive deficits. Before …

[HTML][HTML] Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

A Iyaswamy, X Wang, S Krishnamoorthi… - Redox biology, 2022 - Elsevier
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial
pathological events or factors that cause progressive neuronal loss, and cognitive …

Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

R Mani, A sha Sulthana, G Muthusamy… - Biotechnology and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is an extensive age‐associated neurodegenerative disorder. In
spite of wide‐ranging progress in understanding the AD pathology for the past 50 years …

Three-dimensional real time imaging of amyloid β aggregation on living cells

M Kuragano, R Yamashita, Y Chikai, R Kitamura… - Scientific reports, 2020 - nature.com
Alzheimer's disease (AD) is a progressive disorder of the brain that gradually decreases
thinking, memory, and language abilities. The aggregation process of amyloid β (Aβ) is a …

Withaferin a suppresses beta amyloid in APP expressing cells: studies for tat and cocaine associated neurological dysfunctions

S Tiwari, VSR Atluri, A Yndart Arias… - Frontiers in aging …, 2018 - frontiersin.org
Neurological disorders are the biggest concern globally. Out of~ 36 million human
immunodeficiency virus (HIV) positive people, about 30%–60% exhibit neurological …

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

W Zhou, W Lian, R Yan, H Jia, L Xu, L Wang… - Acta Pharmacologica …, 2020 - nature.com
At present, few available drugs can be used to either improve pathological features or
prevent the progression of Alzheimer's disease (AD). DL0410 ((1, 1′-([1, 1′-biphenyl]-4 …

[PDF][PDF] In silico study of Centella asiatica active compound as BACE1 inhibitor in Alzheimer's disease

N Mawaddani, NRK Wibowo, QHH Nadhira… - J Smart Bioprosp …, 2020 - researchgate.net
Alzheimer (AD) is a chronical neurodegenerative disease which is the 6th leading cause of
death worldwide. About 36 million cases in the world and may increase to 115 million in …

[HTML][HTML] 认知训练对阿尔茨海默病的作用机制及其影响研究

林晓璇, 蓝萍, 车土玲, 苏裕盛 - Hans Journal of Biomedicine, 2023 - hanspub.org
阿尔茨海默病(Alzheimer's Disease, AD) 是一种以进行性认知功能障碍和行为损害为特征的
中枢神经系统退行性病变, 其病理特征是A β, tau 蛋白等异常积累, 主要表现为认知功能障碍和 …

Characterising the effects of genetic risk factors of Alzheimer's disease on synaptic transmission: a functional and structural analysis

L Biasetti - 2020 - sussex.figshare.com
Pathological changes in neural network activity play a key role in Alzheimer's Disease but
the underlying processes remain unclear. Key genetic risk factors are correlated with the …

Role of Withaferin A as a Neuroprotectant Against Beta Amyloid Induced Toxicity and Associated Mechanism

S Tiwari - 2019 - search.proquest.com
Neurological disorders are the biggest concern globally and ageing contributes in
worsening the disease scenarios. In AD or AD like diseases, there is abnormal accumulation …