Although human epidemiological and genetic studies are essential to elucidate the
aetiology of normal and aberrant ocular development, animal models have provided us with …

Highlights•More than 60 zebrafish chemical screens have been reported since 2000.•We
summarize the current practices in design of high-throughput zebrafish screens.•We …

The zebrafish has emerged as an excellent vertebrate model system for studying blood and
lymphatic vascular development. The small size, external and rapid development, and …

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data,
their current form inhibits productive data analysis. The lack of a community-wide …

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation
of biological processes. Compound toxicities, chemical alterations by metabolism …

The receptor for advanced glycation end products (RAGE) is a multiligand cell surface
macromolecule that plays a central role in the etiology of diabetes complications …

Pathological angiogenesis of the retina is a key component of irreversible causes of
blindness, as observed in proliferative diabetic retinopathy, age-related macular …

Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular
remodeling with the production of new endothelial cells, smooth muscle cells …

Acute intensive insulin therapy causes a transient worsening of diabetic retinopathy in type 1
diabetes patients and is related to VEGF expression. Reactive oxygen species (ROS) have …

In the past two decades, zebrafish genetic screens have identified a wealth of mutations that
have been essential to the understanding of development and disease biology. More …