Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

MT Makale, CR McDonald… - Nature Reviews …, 2017 - nature.com
Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

[HTML][HTML] Diffusion tensor imaging of the brain

AL Alexander, JE Lee, M Lazar, AS Field - Neurotherapeutics, 2007 - Elsevier
Diffusion tensor imaging (DTI) is a promising method for characterizing microstructural
changes or differences with neuropathology and treatment. The diffusion tensor may be …

A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia

M Vandermosten, B Boets, J Wouters… - … & Biobehavioral Reviews, 2012 - Elsevier
In this review paper we address whether deficits in reading (ie developmental dyslexia) are
rooted in neurobiological anomalies in white matter tracts. Diffusion tensor imaging (DTI) …

Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study

SL Palmer, C Armstrong, A Onar-Thomas… - Journal of Clinical …, 2013 - ascopubs.org
Purpose The current study prospectively examined processing speed (PS), broad attention
(BA), and working memory (WM) ability of patients diagnosed with medulloblastoma over a 5 …

Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation

J Piao, T Major, G Auyeung, E Policarpio, J Menon… - Cell stem cell, 2015 - cell.com
Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is
associated with significant and irreversible long-term side effects, including cognitive decline …

Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training

L Riggs, J Piscione, S Laughlin, T Cunningham… - Neuro …, 2017 - academic.oup.com
Background. Exercise promotes repair processes in the mouse brain and improves
cognition in both mice and humans. It is not known whether these benefits translate to …

Medulloblastoma in childhood: new biological advances

JR Crawford, TJ MacDonald, RJ Packer - The Lancet Neurology, 2007 - thelancet.com
Medulloblastoma is the most common embryonal tumour in children. Patients with
medulloblastoma are currently staged as average-risk or poor-risk on the basis of clinical …

The cognitive effects of radiotherapy for brain metastases

EJ Lehrer, BM Jones, DR Dickstein, S Green… - Frontiers in …, 2022 - frontiersin.org
Brain metastases are the most common intracranial neoplasm and are seen in upwards of
10-30% of patients with cancer. For decades, whole brain radiation therapy (WBRT) was the …

Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases

EOW Gerdes, Y Zhu, BM Weigand, U Tripathi… - International review of …, 2020 - Elsevier
Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Preventing neurocognitive late effects in childhood cancer survivors

MA Askins, BD Moore III - Journal of child neurology, 2008 - journals.sagepub.com
Neurocognitive late effects are common sequelae of cancer in children, especially in those
who have undergone treatment for brain tumors or in those receiving prophylactic cranial …