Using photo-initiated polymerization reactions to detect molecular recognition

K Kaastrup, HD Sikes - Chemical Society Reviews, 2016 - pubs.rsc.org
Widely used medical diagnostic devices and assays that sense the presence of a particular
molecule in a bodily fluid often rely on either a nanoparticle label or an enzymatic reaction to …

Advances in microfluidic-based DNA methylation analysis

J Li, T Li, X Duan - Nanotechnology and Precision Engineering, 2024 - pubs.aip.org
ABSTRACT DNA methylation has been extensively investigated in recent years, not least
because of its known relationship with various diseases. Progress in analytical methods can …

Substituent Effects of Fluorescein on Photoredox Initiating Performance under Visible Light

WO Choi, YJ Jung, M Kim, H Kim, J Li, H Ko, HI Lee… - ACS …, 2023 - ACS Publications
We demonstrated the effects of substituents in fluorescein on the photoredox catalytic
performance under visible light. For the systematic investigation, the phenyl ring of …

Detection of CpG methylation level using methyl-CpG-binding domain-fused fluorescent protein

M Fujita, M Goto, M Tanaka, W Yoshida - Analytical Methods, 2023 - pubs.rsc.org
Methylation of cytosine to 5-methylcytosine on CpG dinucleotides is the most frequently
studied epigenetic modification involved in the regulation of gene expression. In normal …

Photoinduced radical polymerization by methyl fluoresceins under visible light and the application to signal amplification of hydrogen peroxide

JB Nganga, YJ Jung, Y Si, M Kim, H Ko, GT Hwang… - Dyes and …, 2022 - Elsevier
We investigate visible‒light‒induced radical polymerization initiated by methyl fluorescein
and its derivatives (eg, methyl ether of fluorescein, methyl ether ester of fluorescein, and …

Microfluidic platforms for DNA methylation analysis

R Kurita, O Niwa - Lab on a Chip, 2016 - pubs.rsc.org
In the field of genetics, epigenetics is the study of changes in gene expression without any
change in DNA sequences. Chemical base modification in DNA by DNA methyltransferase …

Microfluidic epigenomic mapping technologies for precision medicine

C Deng, LB Naler, C Lu - Lab on a Chip, 2019 - pubs.rsc.org
Epigenomic mapping of tissue samples generates critical insights into genome-wide
regulations of gene activities and expressions during normal development and disease …

Investigation of dendrimers functionalized with eosin as macrophotoinitiators for polymerization-based signal amplification reactions

K Kaastrup, HD Sikes - RSC Advances, 2015 - pubs.rsc.org
Polymerization-based signal amplification, a technique developed for use in rapid
diagnostic tests, hinges on the ability to localize initiators as a function of interfacial binding …

Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels

KI MacConaghy, DM Chadly, MP Stoykovich, JL Kaar - Analyst, 2015 - pubs.rsc.org
We have developed a novel approach for DNA detection as well as genetic screening of
mutations by uniquely combining DNA-responsive and optically diffracting materials. This …

The heavy-atom effect on xanthene dyes for photopolymerization by visible light

J Yoon, YJ Jung, JB Yoon, K Damodar, H Kim… - Polymer …, 2019 - pubs.rsc.org
We investigated the influence of heavy halogen atoms (Br and I) on xanthene dyes for
polymerization based on visible-light photoredox initiation. Since the heavy atoms directly …