Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Resveratrol, a phytoalexin with a wide range of pharmacological properties is synthesised
by plants in response to stress, injury, infection or UV radiations. As it is a secondary …

The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …

Alzheimer's disease (AD) is a progressive cortex and hippocampal neurodegenerative
disease which ultimately causes cognitively impaired decline in patients. The AD pathogen …

Several important advances have been made in our understanding of the pathways that
lead to cell dysfunction and death in Parkinson's disease and Huntington's disease. These …

In addition to thousands of research papers related to resveratrol (RSV), approximately 300
review articles have been published. Earlier research tended to focus on pharmacological …

Oxidative stress including DNA damage, increased lipid and protein oxidation, are important
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …

Aerobes require oxygen for metabolism and normal free radical formation. As a result,
maintaining the redox homeostasis is essential for brain cell survival due to their high …

Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …