The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

The L-type amino acid transporter LAT1—An emerging target in cancer

P Häfliger, RP Charles - International journal of molecular sciences, 2019 - mdpi.com
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

NOREVA: normalization and evaluation of MS-based metabolomics data

B Li, J Tang, Q Yang, S Li, X Cui, Y Li… - Nucleic acids …, 2017 - academic.oup.com
Diverse forms of unwanted signal variations in mass spectrometry-based metabolomics data
adversely affect the accuracies of metabolic profiling. A variety of normalization methods …

Metabolomics in cancer biomarker discovery: current trends and future perspectives

EG Armitage, C Barbas - Journal of pharmaceutical and biomedical …, 2014 - Elsevier
Cancer is one of the most devastating human diseases that causes a vast number of
mortalities worldwide each year. Cancer research is one of the largest fields in the life …

The serum amino acid profile in COVID-19

A Atila, H Alay, ME Yaman, TC Akman, E Cadirci… - Amino acids, 2021 - Springer
The pandemic of the coronavirus disease (COVID-19) caused by SARS-CoV-2 affects
millions of people worldwide. There are still many unknown aspects to this infection which …

Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites

R Gao, C Wu, Y Zhu, C Kong, Y Zhu, Y Gao, X Zhang… - Gastroenterology, 2022 - Elsevier
Background & Aims Studies have reported abnormal gut microbiota or circulating
metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture …

Colorectal cancer detection using targeted serum metabolic profiling

J Zhu, D Djukovic, L Deng, H Gu… - Journal of proteome …, 2014 - ACS Publications
Colorectal cancer (CRC) is one of the most prevalent and deadly cancers in the world.
Despite an expanding knowledge of its molecular pathogenesis during the past two …

Pharmacometabonomics: data processing and statistical analysis

J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …

Performance evaluation and online realization of data-driven normalization methods used in LC/MS based untargeted metabolomics analysis

B Li, J Tang, Q Yang, X Cui, S Li, S Chen, Q Cao… - Scientific reports, 2016 - nature.com
In untargeted metabolomics analysis, several factors (eg, unwanted experimental &
biological variations and technical errors) may hamper the identification of differential …

Metabolomics in diagnosis and biomarker discovery of colorectal cancer

A Zhang, H Sun, G Yan, P Wang, Y Han, X Wang - Cancer letters, 2014 - Elsevier
Colorectal cancer (CRC), a major public health concern, is the second leading cause of
cancer death in developed countries. There is a need for better preventive strategies to …